How-to guides# Calculating polygenic scores# How do I prepare my input genomes? How to set up a samplesheet How to use scoring files in the PGS Catalog How to apply multiple scores in parallel How do I normalise calculated scores across different genetic ancestry groups? How do I speed up computation times and avoid re-running code? Making genomic data and scorefiles compatible# How to use a custom scoring file How to liftover scoring files to match your input genome build How to set effect type of variants in a scoring file Reference database# How do I set up the reference database? Working in different environments# How do I run pgsc_calc on larger datasets and more powerful computers? How do I run the pipeline on an M1 Mac? How do I run pgsc_calc in an offline environment? How do I launch pgsc_calc using cloud executors? Running the PGS Catalog Calculator via the All of Us workbench Working with complex datasets# How to get a copy of the standardised genomic data How to set parameters in a file Other# How do I change the version or update pgsc_calc?