How-to guides

Calculating polygenic scores

• How do I prepare my input genomes?
• How to set up a samplesheet
• How to use scoring files in the PGS Catalog
• How to apply multiple scores in parallel

Making genomic data and scorefiles compatible

• How to use a custom scoring file
• How to liftover scoring files to match your input genome build
• How to set effect type of variants in a scoring file

Working in different environments

• How do I run pgsc_calc on larger datasets and more powerful computers?
• How do I run the pipeline on an M1 Mac?

Working with complex datasets

• How to get a copy of the standardised genomic data
• How to set parameters in a file